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Studies Find Lasting COVID Risks: Brain Changes in Infants, Stroke Risk in Adults

Nonhospitalized COVID-19 patients had a 73% higher risk of stroke up to one year post-infection compared with other acute respiratory infections, study finds.

  • Using PCORnet data from April 1, 2022–April 30, 2023, a study in CDC's Emerging Infectious Diseases found even mild COVID-19 raises stroke and thrombotic risk up to one year after illness.
  • Earlier studies focused on the first 30 days after infection, leaving longer-term thrombotic risk unclear and many prior analyses centered on pre-Delta and Delta variant study periods.
  • Measured data show an overall incidence ratio of 1.63, with nonhospitalized patients with COVID-19 facing a 73% increased risk for thrombotic events in days 31–365, risk ratios 1.73 versus 1.14 in hospitalized patients.
  • Clinicians and public-health officials should increase stroke awareness and monitoring, as authors say data support prevention, chronic-disease management, and COVID-19 vaccination to reduce severe illness and thrombotic risks.
  • Investigators say mechanisms remain uncertain, including endothelial cell damage, viral-triggered exaggerated immune response, and persistent microthrombi; longitudinal follow-up and future studies should clarify long-term cardiovascular consequences.
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Harvard University broke the news in Harvard, United States on Friday, October 31, 2025.
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