Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

Steroid Dangers and Safe Autoimmune Treatments - LewRockwell

Many of the problems we currently see in medicine are not new, but rather iterations of things that have been forgotten and occurred countless times in the past. For example, the COVID mRNA vaccines are not the first time the medical field has experienced irrational exuberance for a dubious remedy, even as some of their colleagues spoke out against it (at great risk to their professional standing). Here, we’ll look at what happened with corticos…

From Vulnerability to Visibility: The Pandemic’s Impact on Autoimmune Communities

by Mia Feldman Graphic design by Yu-Wen Jan Autoimmune diseases, such as Crohn’s disease, rheumatoid arthritis (RA), and lupus, are a class of conditions in which the body’s immune system mistakes its own healthy tissue for foreign invaders, leading to severe inflammatory reactions. It is well established that individuals with autoimmune diseases are at high risk of adverse response to infections; back in 1953, a landmark study found that among …

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

Human immune system (HIS) mice constructed in various ways are widely used for investigations of human immune responses to pathogens, transplants, and immunotherapies. In HIS mice that generate T cells de novo from hematopoietic progenitors, T cell-dependent multisystem autoimmune disease occurs, most rapidly when the human T cells develop in the native NOD.Cg- Prkdcscid Il2rgtm1Wjl (NSG) mouse thymus, where negative selection is abnormal. Disea…