US EditionSTAT3 DNA Decoy Shows Tumor Control in Cat Cancer Trial
A novel therapy targeting the STAT3 protein showed disease control in 35% of treated cats with minimal side effects, suggesting potential benefits for human head and neck cancer patients.
- Researchers reported the first clinical trial in domesticated pet cats for head and neck squamous cell carcinoma , with a 35% response rate controlling disease and showing minimal side effects.
- Because head and neck squamous cell carcinoma is notoriously deadly, Dr. Jennifer Grandis, study first author, tested the drug on pet cats after discussing with Grandis's sister, a veterinarian, noting most cats survive only two to three months post-diagnosis.
- Trial data show 20 cats enrolled, seven responders lived an average 161 days post-treatment, with only mild anaemia as a side effect.
- The research team is now working with a small biotech company to advance the compound into clinical trials for pets and humans, while study co-author Professor Daniel Johnson said this shows targeting a difficult transcription factor is possible.
- Jak, a 9-year-old black domestic shorthair, lived over eight months after weekly treatments, which blocked STAT3 protein and raised PD-1 protein; Dr. Jennifer Grandis, UC San Francisco, said, `Under the microscope, these cancers look very similar, if not identical`.
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New Cancer Therapy for Cats ‘Could Save Human Lives’ Too
A new targeted treatment for cats with head and neck cancers may also help save human lives in the future, say scientists. The first-ever clinical trial of the therapy found that more than a third of felines who received treatment (35%) had their disease controlled with minimal side effects. And the drug will likely be […] The post New Cancer Therapy for Cats ‘Could Save Human Lives’ Too appeared first on Good News Network.
Carcinomas in the head and neck area are treacherous. US-American researchers have tested a novel cancer therapy. Why cats such as hangovers "Jak" could be crucial for cancer research in humans.
The Independent
The Independent (US)Cats may hold key to treating human cancer, scientists say
First-of-its-kind drug was initially conceptualised to treat human head and neck cancers
First clinical trial in cats tests targeted therapy for deadly head and neck cancer
Researchers have reported results from the first-ever clinical trial of a new class of targeted therapy in pet cats with head and neck squamous cell carcinoma (HNSCC)-a cancer which is notoriously deadly and difficult to treat.
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