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South Africa: Unpacking the HIV Jab That Could Dramatically Reduce New Infections

The rollout targets about 500,000 people at 360 clinics as South Africa expands access to a six-monthly HIV prevention shot.

  • On Friday, June 5, 2026, South Africa began rolling out lenacapavir, a twice-yearly HIV prevention injection, at public sector clinics across the country.
  • Studies found the antiretroviral drug nearly 100% effective in preventing HIV, prompting Science to name it a 2024 "breakthrough." Safety trials included adolescents aged 16 and 17 and pregnant women.
  • Before receiving the injection, users must test negative for HIV and take lenacapavir tablets for two days. The drug forms a depot under the skin, releasing medication slowly over six months.
  • The initial rollout targets around half a million people at 360 clinics in high-infection areas, addressing South Africa's epidemic where annual new infections remain stubbornly high at more than 140,000.
  • South Africa plans to scale up access in coming years, targeting prices of no more than $40 per person annually through generic manufacturers. Gilead issued licenses to six companies for global production.
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Lean Left

South Africa rolls out game-changing HIV shot amid funding shortfalls

A new twice-yearly HIV prevention injection could transform South Africa's fight against the epidemic — but U.S. aid cuts and limited doses threaten to slow its impact.

·Washington, United States
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mambaonline.com broke the news on Thursday, June 4, 2026.
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