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Human Antibodies Drive Breakthrough in Broad-Spectrum Snake Antivenom

  • Tim Friede, bitten by venomous snakes over 200 times mainly on purpose at his Wisconsin home, has developed immunity that scientists are studying.
  • Friede acquired immunity by injecting increasingly larger doses of venom from many deadly snakes during nearly 18 years of self-immunization.
  • Researchers led by Centivax identified two antibodies in Friede’s blood that neutralize venom from multiple snake species including cobras, mambas, and kraits.
  • Dr. Jacob Glanville said the antibody cocktail provided full protection for 13 of 19 deadly snake species tested in mice, with partial protection for others.
  • While the findings suggest a path to broad-spectrum antivenom, experts emphasize this early research requires years more before human trials and is not a replacement for medical advice.
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Nature broke the news in United Kingdom on Friday, May 2, 2025.
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