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Shape-shifting cell channel reveals new target for precision drugs
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Shape-shifting cell channel reveals new target for precision drugs
A cellular gate, called PANX1, accommodates cargo of vastly different sizes. Study is first to find the channel uses a ring of amino acids to form a flexible gate that dilates and constricts. Researchers also found a common antimalarial drug binds to a previously unknown site in PANX1 to control the gate.
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