Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Study reveals that group B [FeFe]-hydrogenase is the primary enzyme driving fermentative hydrogen production in the healthy human gut, mainly through Bacteroides species. These genes are significantly depleted in Crohn’s disease, indicating a metabolic shift and altered hydrogen cycling dominated by respiratory bacteria

Nutrition and microbiome research highlights from NeuroGASTRO 2025

Modifying the progression of metabolic, immune, and age-related diseases through the gut microbiome The development of the gut microbiome and alterations linked to health and disease across the lifespan was the focus of a symposium. Cristina Campoy, PhD, MD, from the University of Granada, covered the association between the developmental trajectory of the healthy human gut microbiome and neurodevelopment during the first 5 years of life1. Findi…

Environmental News Network - Rebalancing the Gut: How AI Solved a 25-year Crohn’s Disease Mystery

UC San Diego researchers have settled a decades-long debate surrounding the role of the first Crohn’s disease gene to be associated with a heightened risk for developing the auto-immune condition.

Breakthrough Discovery: AI Unraveling a 25-Year Mystery in Crohn’s

Researchers at the University of California San Diego School of Medicine have made significant strides in our understanding of the immune system’s response to gut inflammation, particularly in the context of Crohn’s disease, a chronic inflammatory bowel condition. This intricate disease is characterized by a complex interplay of immune cells, including a specialized group known […]

Rebalancing the Gut: How AI Solved a 25-Year Crohn’s Disease Mystery

The human gut contains two types of macrophages, or specialized white blood cells, that have very different but equally important roles in maintaining balance in the digestive system. Inflammatory macrophages fight microbial infections, while non-inflammatory macrophages repair damaged tissue. In Crohn’s disease — a form of inflammatory bowel disease (IBD) — an imbalance between these two types of macrophages can result in chronic gut inflammati…