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Nose Spray Made From Toad Venom Compound Quickly Eases Depression For Weeks in Clinical Trial

Summary by Science Alert
In a quest to improve patients' mental health, it seems scientists are working their way through a list of every psychedelic 'party' drug of the past century.

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A relatively obscure psychedelic compound, derived from frog venom, is being investigated for its antidepressant potential. According to a study published this Tuesday in the scientific journal Journal of the American Medical Association, a single dose of a nasal spray based on mebufotenin or 5-MeO-DMT, present in the Sonora Desert frog also known as Colorado frog, may be a safe and rapid option for patients with difficult-to-treat depression. A…

·Rio de Janeiro, Brazil
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Experimental nasal spray based on a psychoactive substance 5-MeO-DMT helped to reduce symptoms of depression that did not lend itself to standard treatment; improvements in patients began to be detected within two days of a single application and the effects continued for eight weeks of observation; the results of the clinical study were published in JAMA magazine.

An unusual candidate against persistent depression: In a clinical study, a synthetically produced active substance, which also occurs in the secretion of a North American toad, has alleviated more complaints than a very low comparator dose. The effect was rapid and continued over several weeks. Whether the treatment permanently helps, however, must first be shown. Oxford (England). If [...] The post Psychedelic: Toad poison helps in treatment-re…

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A single sniff of a psychedelic substance found in toad venom, among other things, relieved symptoms for weeks in people with hard-to-treat depression. Participants did not trip for hours: the trip was so short that most were deemed ready to go home after 2 hours. About one in three people […] More science? Read the latest articles on Scientias.nl.

·Middelharnis, Netherlands (Kingdom of the)
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Science Alert broke the news in Canberra, Australia on Monday, October 26, 2026.
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