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Landmark Map of Human Brain’s Gene Activity Holds Clues to Alzheimer’s Disease and More

The map links inherited risk to more than 14,000 genes and shows shared and disease-specific patterns across Alzheimer’s, Parkinson’s and schizophrenia.

Summary by Nature
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02947-xThe atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.

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Laboratory assistant holds a hemisphere of a healthy human brain at Belle Idee University Hospital in Chene-Bourg, near Geneva. March 14, 2011. REUTERS/Denis Balibouse Scientists created a detailed map of gene activity in a crucial part of the brain called prefrontal cortex, obtaining new insights into normal development and major brain diseases such as Alzheimer's, Parkinson's and schizophrenia. In nine separate studies, researchers examined ch…

·Rio de Janeiro, Brazil
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An extensive map of brain gene activity shows biological changes that may be involved in health and the possibility of disease

·Madrid, Spain
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Nature broke the news in London, United Kingdom on Wednesday, September 23, 2026.
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