Clinical Trial Examines Whether Ambroxol Can Slow Dementia in People with Parkinson's
EUROPE, JUN 30 – A 12-month trial with 55 participants showed Ambroxol stabilized psychiatric symptoms and brain damage markers, offering potential brain protection in Parkinson's disease dementia.
- A 12-month clinical trial conducted in Canada and published today in JAMA Neurology evaluated Ambroxol's effects in a group of 55 individuals diagnosed with dementia associated with Parkinson's disease.
- Researchers conducted the study because current therapies only address symptoms and do not stop the progression of Parkinson's dementia.
- The trial randomized participants to daily Ambroxol or placebo and monitored memory, psychiatric symptoms, and a brain damage marker called GFAP.
- Results showed Ambroxol was safe, well-tolerated, reached therapeutic brain levels, stabilized psychiatric symptoms, and maintained stable GFAP levels unlike placebo.
- Pasternak and his team plan a follow-up trial later in 2025 focused on cognition, hoping further research confirms Ambroxol’s potential to change Parkinson's dementia's course.
15 Articles
15 Articles


Cough medicine turned brain protector? Ambroxol may slow Parkinson’s dementia
Ambroxol, long used for coughs in Europe, stabilized symptoms and brain-damage markers in Parkinson’s dementia patients over 12 months, whereas placebo patients worsened. Those with high-risk genes even saw cognitive gains, hinting at real disease-modifying power.
Common cough medicine could slow dementia progression, scientists say
A year-long clinical trial has found that Ambroxol, a cough syrup commonly sold across Europe, could potentially slow the progression of dementia in Parkinson's disease patients.The study, published in JAMA Neurology, monitored 55 participants with Parkinson's dementia and discovered that psychiatric symptoms remained stable in those taking the medication, while the placebo group experienced worsening symptoms.The research offers hope for the ne…
Cough medicine could help protect against form of dementia, study finds
A COMMON cough medicine could help protect against dementia. A study found that it prevented people with Parkinson’s develop the memory-destroying disease. GettyA cough medicine prescribed for decades in Europe – called ambroxol – could stabilise the progression of Parkinson’s dementia[/caption] Around 145,000 people in the UK have Parkinson’s, a progressive brain disease that affects movement – but they’re also more likely to develop certain fo…
Cough medicine Ambroxal shows potential to slow Parkinson's-related dementia
Dementia poses a major health challenge with no safe, affordable treatments to slow its progression. Researchers at Lawson Research Institute (Lawson), the research arm of St. Joseph's Health Care London, are investigating whether Ambroxol—a cough medicine used safely for decades in Europe—can slow dementia in people with Parkinson's disease.
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