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Human Receives AI-Designed Virus for the First Time
Radical Numerics said the cocktail cleared the patient’s resistant isolate in lab tests, while human results remain undisclosed.
San Francisco-based Radical Numerics announced this week that it administered an AI-designed bacteriophage cocktail to a human patient under a compassionate-use arrangement, marking the first clinical use of Omnii-1-designed phages.
Researchers are seeking therapeutic alternatives to combat the rise of antimicrobial-resistant bacteria, which render antibiotics increasingly ineffective. Antibiotic resistance is a growing global health threat.
Omnii-1, unveiled by the company this week, designed the bacteriophages used in treatment. The model 'performed competitively' against a specialized model at predicting phage-host interactions, the research write-up notes.
Unfortunately, Radical Numerics has not released results from human administration, citing patient privacy. The company noted observations from a single patient do not establish safety or efficacy.
Similar to work from Stanford University and the Arc Institute last year, the cocktail eliminated the patient's antibiotic-resistant isolate in vitro, so there is at least a success on record there.