Scientists identify the neuroblastoma cells that signal poor outcomes

Scientists identify the neuroblastoma cells that signal poor outcomes

Neuroblastoma is the most common solid tumor found outside the brain in children, yet why some children respond well to treatment while others do not has remained poorly understood. St. Jude Children's Research Hospital scientists and their collaborators built one of the most comprehensive datasets of neuroblastoma cells to date, using it to define the tumor's cell types and identify a gene signature marking a malignant cell population tied to p…

Gene Signature Exposes Hidden Neuroblastoma Cells That Drive Poor Outcomes

St. Jude scientists and collaborators built a comprehensive single-cell dataset and patient-derived models to identify a malignant mesenchymal cell population in neuroblastoma that is linked to treatment resistance and poor outcomes.