US EditionCRISPR Takes a Bold Leap Toward Silencing Down Syndrome's Extra Chromosome
5 Articles
5 Articles
CRISPR takes a bold leap toward silencing Down syndrome's extra chromosome
Scientists have taken an important step toward a gene therapy that could one day turn off the extra genetic material that causes Down syndrome (DS). Down syndrome is a genetic condition caused by an extra chromosome 21 (and consequently hundreds of triplicate genes) that leads to developmental and neurological issues. According to the Washington-based National Down Syndrome Society, approximately 1 in every 640 babies in the United States is bor…
That gene therapy could allow treatments never thought of before had been understood for a long time and with the passing of the years the application of the technique cut-and-sewn DNA has allowed to achieve results only hoped for in different fields of medicine. A new method based on the Crispr-Cas9 has allowed to take a first step towards ...
Down Syndrome Chromosomal Therapy Draws Closer
Gene editing has been able to silence the extra chromosome that is mostly responsible for Down syndrome (DS) in a cell-based study that could be the first step towards therapeutic treatment. The approach uses a modified form of CRISPR-Cas9 to alter precise sections of DNA. Researchers used this to insert the X-inactivation specific transcript (XIST) gene to deactivate X chromosomes in female cells, thereby correcting chromosomal triplication. Th…
In every female cell, there is a gene that silences an entire chromosome. Otherwise, women would receive a double dose of all their X genes. Researchers at Harvard have now utilized that mechanism to disable the extra chromosome 21 in Down syndrome in the lab. Women have two X chromosomes, but they actually use […] More science? Read the latest articles on Scientias.nl.
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