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Scientists finally explain why chronic constipation treatments often fail

Nagoya University researchers reveal a bacterial mechanism causing chronic constipation resistant to standard laxatives, affecting millions including Parkinson's patients, with new treatment targets identified.

Summary by Science Daily
A newly discovered bacterial duo may be the hidden cause of chronic constipation. The two microbes break down the colon’s protective mucus layer, leaving stool dry and hard — a problem traditional laxatives don’t fix. Parkinson’s patients, who often struggle with constipation years before tremors appear, have higher levels of these bacteria. Blocking the bacteria’s mucus-destroying enzyme prevented constipation in mice, hinting at a new treatmen…

8 Articles

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One study highlights how excessive degradation of mucin, facilitated by bacteria, generates hard and dry stools, leading to constipation

·Los Angeles, United States
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Medical Xpress broke the news in Douglas, United Kingdom on Thursday, February 19, 2026.
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