US EditionScientists Create Replica Womb Lining, Implant Early Embryos
Researchers recreated womb lining in lab devices to observe embryo implantation and screened over 1,100 drugs for miscarriage prevention, advancing understanding of early pregnancy.
- On Tuesday, Wu and colleagues in China recreated primitive womb-like environments using uterine-lining cells inside tiny plastic womb-on-chip devices and published in Cell and Cell Stem Cell.
- Because implantation is hidden early in pregnancy, teams recreated the lining using donor uterine-lining cells to study human embryo implantation and help people affected by miscarriage and infertility.
- Wu's team recreated the lining and then placed embryos, using donor tissue to place donated human embryos and embryoids inside tiny devices to observe implantation and screen drugs.
- Peers praised the advance and its molecular insights, saying the models reveal implantation at the molecular level and represent an important advance, Robin Lovell-Badge and Peter Rugg-Gunn noted.
- Amid praise, ethicists flagged potential future uses beyond basic research, warning of ectogenesis risks and studying embryos past the 14-day development limit, though researchers deny pursuing that.
8 Articles
8 Articles
System replicates womb lining to 'listen in' to embryo-mother interactions during implantation
By engineering a system replicating the womb lining with high biological accuracy, researchers at the Babraham Institute and Stanford University have been able to study the implantation of human embryos, opening up this enigmatic process to investigation. This now allows scientists to study interactions between the womb and embryo, and look for the causes behind implantation failure, a main reason for early pregnancy loss, and the origins of pre…
Researchers are getting organoids pregnant with human embryos
At first glance, it looks like the start of a human pregnancy: A ball-shaped embryo presses gently into the receptive lining of the uterus and then grips tight, burrowing in as the first tendrils of a future placenta appear. This is implantation—the moment that pregnancy officially begins. Only none of it is happening inside a…
Scientists learn more about how human embryos implant using artificial wombs
Scientists have developed an experimental way to study how human embryos implant in a uterus, which may provide new insights into why miscarriages occur and how they can be prevented.
Premature babies could be more likely to survive and be healthier in the long term thanks to this innovative technology. It is an artificial uterus designed to replicate the conditions of staying inside the mother’s body. Continue reading...
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