Chemotherapy Nerve Damage Linked to Immune Cell Stress Pathway Activation

Chemotherapy nerve damage linked to immune cell stress pathway activation

Scientists at Wake Forest University School of Medicine, in collaboration with researchers at Weill Cornell Medicine, have made a breakthrough in understanding why many cancer patients develop nerve damage after chemotherapy. Their new study reveals that a stress response inside certain immune cells can trigger this debilitating side effect. This discovery could open the door to new ways to prevent or treat nerve damage in cancer patients.

How Chemotherapy Triggers Nerve Damage, and How to Stop It

A new study reveals that chemotherapy-induced nerve pain arises from a stress response in immune cells that triggers inflammation and neurotoxicity. Researchers found that activating a cellular stress sensor called IRE1α causes nerve damage and pain during chemotherapy, but blocking it prevents both in mice.

Scientists Identify Crucial Mechanism Driving Chemotherapy-Induced Nerve

A groundbreaking discovery by scientists at Wake Forest University School of Medicine, in collaboration with Weill Cornell Medicine, sheds critical light on a pervasive and painful complication faced by cancer patients undergoing chemotherapy: chemotherapy-induced peripheral neuropathy (CIPN). This debilitating condition, characterized by numbness, tingling, and excruciating pain predominantly in the hands and feet, has long […]

Researchers Uncover Key Mechanism Behind Chemotherapy-Induced Nerve Damage

Scientists at Wake Forest University School of Medicine have made a breakthrough in understanding why many cancer patients develop nerve damage after chemotherapy.