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Researchers reveal new approach to obesity drug development

University of Pittsburgh researchers identified two enzymes blocking leptin and showed a gene inhibitor can restore fat-specific weight loss of about 50% in rodents.

Summary by WLKY
Patients with obesity sometimes have leptin resistance, and the "full" feeling does not get through to the brain. The new research isolates enzymes that act like valves, preventing the flow of leptin.

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Researchers reveal new approach to obesity drug development

Patients with obesity sometimes have leptin resistance, and the "full" feeling does not get through to the brain. The new research isolates enzymes that act like valves, preventing the flow of leptin.

·Greenville, United States
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WLKY broke the news in Louisville, United States on Thursday, March 19, 2026.
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