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Researchers identify mechanism explaining chemical disruption of sex hormones

Activation of pregnane X receptor by rifampicin doubled sex hormone–binding globulin levels in volunteers, revealing a key mechanism behind endocrine disruption by chemicals.

Summary by News Medical
Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones.

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Medical Xpress broke the news in on Thursday, March 12, 2026.
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