Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides See letter by Ferré and Michaelides and article by Fava et al To the Editor: We appreciate the opportunity to respond to the letter by Drs Ferré and Michaelides1 regarding the mechanistic characterization of esmethadone (S-methadone). In their letter, Ferré and Michaelides raise two m…