Rare gene variants may multiply Alzheimer's disease risk

Rare gene variants may multiply Alzheimer's disease risk

Alzheimer's disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2, have emerged as some of the most important modifiers of Alzheimer's disease risk, as certain genetic variants in the gene appear to protect against the disease. For example, the protective P522R variant in PLCG2 increases PLCγ2 enzyme activity, suggesting that enhanced enzyme function may help prevent disease development.