US EditionPython blood compound could lead to new weight loss therapies
Para-tyramine-O-sulfate (pTOS) rises 1,000-fold after pythons eat and reduces appetite and weight in mice without typical side effects, suggesting new obesity treatments.
- On Thursday, researchers reported that a python metabolite called pTOS suppresses appetite in mice without nausea or muscle loss associated with current weight-loss drugs.
- Led by University of Colorado Boulder professor Leslie Leinwand, scientists from Stanford University and Baylor University analyzed blood samples from pythons fed once every 28 days, identifying at least 208 metabolites that surge after feeding.
- The metabolite pTOS acts on the hypothalamus to regulate hunger, distinguishing it from GLP-1 medications like Wegovy, which often cause gastrointestinal issues and muscle loss, according to the study.
- Leinwand and her team formed Arkana Therapeutics to commercialize these findings, targeting therapies for obesity and age-related muscle loss, or sarcopenia.
- Researchers plan to explore additional metabolites found in pythons, though human applications remain far off and this research is for informational purposes, not medical advice.
11 Articles
11 Articles
Is Python Blood The Secret To Healthier Weight Loss? New Research Says It Might Be
New research suggests python blood could hold the key to a new weight-loss drug, as the snake metabolite suppresses appetites in mice. It is the appetite-suppressing compound in python blood that allows the snakes to basically survive on what humans would call an extreme “crash diet.” For example, pythons can eat huge meals, eating an entire animal in one sitting, yet go months, or even years, without eating anything at all. It is this unique ab…
Something in Python Blood Could Be The Future of Weight Loss
Scientists discovered GLP-1 mimics like Ozempic by way of the Gila monster, and now, a metabolite in python blood is also showing promise for future weight loss treatments – potentially minus some of the uncomfortable side-effects of GLP-1 drugs.
Researchers believe that the molecule could have a similar type of effect in humans as semaglutide.
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