Protein Made by Stressed Cancer Cells Helps Tumors to Evade Immune Attack

Protein made by stressed cancer cells helps tumors to evade immune attack

A protein made by stressed cancer cells helps lung and pancreatic tumors evade the immune system, a new study shows.

Cancer stress protein helps tumors hide from immune system

A protein made by stressed cancer cells helps lung and pancreatic tumors evade the immune system, a new study shows. Led by researchers from NYU Langone Health, the work found that new drugs designed to block the action of a protein called lipocalin 2 (LCN2) slowed cancer growth in mice by enabling the immune system to target tumor cells. The drugs made aggressive cancers more vulnerable to immunotherapies, which help the immune system attack ca…

The integrated stress response promotes immune evasion through lipocalin 2

Cancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy1. ISR signals converge on activating transcription factor 4 (ATF4), which controls cell-intrinsic transcriptional programs that are involved in metabolic adaptation, survival and growth2,3. However, whether the ISR–ATF4 axis influences anti-tumour immune responses remains mostly unknown. Here we show that loss of ATF4 decreases tumour progression con…

Tumor Survival Boosted by Cancer Stress Protein’s Role in Immune Evasion

In a groundbreaking study published recently in Nature, researchers from NYU Langone Health have unveiled a sophisticated mechanism by which certain aggressive tumors, including those in the lung and pancreas, evade the immune system. The discovery centers on a protein called lipocalin 2 (LCN2), produced by cancer cells under chronic stressful conditions, which acts as […]