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Montreal Discovery Elucidates the Exhaustion of Immune Cells

Summary by Acadie Nouvelle
Montreal researchers have pointed out a factor that explains why immune cells that fight chronic infections and even cancer end up exhausting and losing their effectiveness.
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Researchers at the National Institute of Scientific Research (INRS) and McGill University have discovered a key factor capable of preserving the energy of T-cells CD8+, a breakthrough leading to new strategies to strengthen immunity in the context of chronic infections or cancers. In the face of chronic infections or certain cancers, CD8+ T-cells – true soldiers of the immune system – end up exhausting. They become less effective and respond les…

Acadie NouvelleAcadie Nouvelle
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lechodelarivenord.calechodelarivenord.ca

Montreal researchers have pointed out a factor that explains why immune cells that fight chronic infections and even cancer end up exhausting and losing their effectiveness.

A team led by Professor Simona Stäger makes promising progress in the fight against chronic infections Simona Stäger, expert in infectious disease immunology at the Armand-Frappier Santé Biotechnologie Center of the INRS. Photo: INRS When faced with chronic infections or certain cancers, CD8+ T cells—the true soldiers of the immune system—eventually become exhausted. They become less effective and respond less well to threats. This weakening is …

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INRS broke the news in on Thursday, July 24, 2025.
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