Preliminary Study Finds a Clue in the Quest to Help Diagnose CTE in the Living
The early study found higher blood levels of eMTBR-tau243 in 11 autopsy-confirmed CTE patients, but researchers said larger studies are needed.
- Washington University researchers found a blood test detecting a toxic protein can identify advanced CTE, a condition currently only diagnosable after death.
- Scientists stumbled onto the potential biomarker while studying Alzheimer, discovering that levels of the protein were also elevated in patients with advanced CTE.
- The test achieved an AUC of 0.97 for detecting advanced CTE, though accuracy dropped to 0.64 for early-stage disease according to findings published late Friday in JAMA.
- Rudolph Castellani, a neuropathologist at Northwestern University, cautioned the findings remain preliminary and require larger studies, noting the test cannot distinguish CTE from Alzheimer alone.
- If validated, the test could allow doctors to diagnose CTE in living patients, potentially facilitating clinical trials for treatments currently limited by the inability to confirm diagnosis.
23 Articles
23 Articles
Preliminary study finds a clue in the quest to help diagnose CTE in the living
Scientists stumbled onto a hint that measuring a toxic protein tied to Alzheimer’s disease just might one day be useful in diagnosing a different brain disease in football players and others who have suffered repeated blows to the head
American scientists have found a protein marker in the blood that can help detect chronic traumatic encephalopathy (CTE) in human life, a brain disease that develops in the face of multiple blows to the head, and the diagnosis can still be confirmed only after the patient's death. The results of the study are published in JAMA's scientific journal.
Preliminary study finds a clue in quest to help diagnose CTE in living
Scientists stumbled onto a hint that measuring a toxic protein tied to Alzheimer's disease just might one day be useful in diagnosing a different brain disease in football players and others who have suffered repeated blows to the head.
Washington: Scientists have come up with an indication that measuring the level of toxic protein associated with Alzheimer ' s disease may one day be useful in diagnosing another brain disease among football players and others who have been repeatedly hit on the head. Doctors assess symptoms such as mood swings and memory loss, in an effort to determine whether patients have cerebral morbidity [...]
Small study finds a hint that an Alzheimer’s protein may help diagnose CTE
Scientists stumbled onto a hint that measuring a toxic protein tied to Alzheimer’s disease just might one day be useful in diagnosing a different brain disease in football players and others who have suffered repeated blows to the head.
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