Predicting granule size via in-line NIR spectroscopy during fluidized bed foam granulation and drying

Predicting granule size via in-line NIR spectroscopy during fluidized bed foam granulation and drying

Abstract Wet granulation-a unit operation involving mixing polymeric binders with powdered formulations-is well established in the pharmaceutical industry, playing a major role in the manufacturing of oral solid dosage forms and improving the physical properties of granules (size, density, shape factor, etc.) before tableting. The foaming properties of aqueous polymeric binders prove useful for binder delivery within the mixing vessel, with foam…