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Portable tuberculosis test achieves 100% sensitivity and specificity in clinical samples

Summary by Medical Xpress
Princeton University and collaborators have developed SHINE-TB, a one-sample, parallelized reaction amplification and detection CRISPR assay that detects Mycobacterium tuberculosis directly from sputum, achieving 100% sensitivity (6 of 6) and 100% specificity (7 of 7) versus culture in 13 blinded clinical samples.

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Portable tuberculosis test achieves 100% sensitivity and specificity in clinical samples

Princeton University and collaborators have developed SHINE-TB, a one-sample, parallelized reaction amplification and detection CRISPR assay that detects Mycobacterium tuberculosis directly from sputum, achieving 100% sensitivity (6 of 6) and 100% specificity (7 of 7) versus culture in 13 blinded clinical samples.

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Medical Xpress broke the news in on Tuesday, August 12, 2025.
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