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Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures
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Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures
BackgroundMonoclonal antibodies targeting pathological tau have repeatedly failed in Alzheimer’s disease (AD) clinical trials. Whether plasma phosphorylated tau (pTau) exhibits dynamic progression or cognitive relevance in population-based cohorts remains unclear.Methods...
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