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Pitt study uncovers a novel trigger of deadly form of ovarian cancer

  • On March 14 2025, researchers at the University of Pittsburgh published a Cancer Discovery study identifying a novel trigger of high-grade serous ovarian cancer , the most common form of ovarian cancer.
  • HGSOC often begins in the fallopian tubes, where healthy epithelial cells transform into precursor lesions known as serous tubal intraepithelial carcinoma .
  • The trigger is a subset of progenitor cells, named 'high-risk MSCs', that reside in the fallopian tube stroma and become reprogrammed by tumor cells to support cancer growth, with these cells being more common in women with a higher risk of ovarian cancer.
  • Lan Coffman, co-senior author and associate professor at Pitt School of Medicine, stated that stromal changes in the fallopian tube have a causative role in ovarian cancer initiation and that compounds secreted by high-risk MSCs detectable in the bloodstream could act as biomarkers for early-stage ovarian cancer.
  • This discovery, revealing that high-risk MSCs promote DNA damage and help mutated cells survive, could pave the way for improved prevention and detection strategies for HGSOC, which kills over 12,000 women in the U.S. Annually and is the leading cause of death from gynecologic cancer in the Western world.
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Medical Xpress broke the news in on Friday, March 14, 2025.
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