PEG Alternative Minimizes Immunogenicity from LNP-Based Therapies
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PEG Alternative Minimizes Immunogenicity from LNP-Based Therapies
A new material developed at Cornell University could significantly improve the delivery and effectiveness of mRNA vaccines by replacing a commonly used ingredient in lipid nanoparticles (LNPs) that may trigger unwanted immune responses in some people. Traditional lipid nanoparticle formulations for mRNA delivery contain the polymer poly(ethylene) glycol (PEG), which is widely used in drug delivery carriers, but has recently been linked to immuno…
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