The risks of many diseases are linked to birth order, study finds

Birth order and disease risk across the human phenome - Nature Health

Birth-order effects on disease risk have been studied for individual conditions but have not been systematically assessed at phenome-wide scale in large sibling claims cohorts. We apply two complementary designs, a between-family matched cohort (1.6 million pairs) as a high-powered phenome-wide scan, and a within-family sibling comparison (5.1 million families) as an internally controlled sibling contrast, to 569 diseases in Merative MarketScan …

Birth order may influence your disease risk later in life, study finds

Whether you are first-born or second-born may be associated with your risk of developing certain diseases, according to a new study published in Nature Health.

The risks of many diseases are linked to birth order, study finds

The order in which a person was born may have an impact on their risk for developing disorders or diseases, a new study has found.

Study maps how birth order tracks disease risk across 10 million siblings

Researchers analyzing claims from more than 10 million siblings linked first-born status to higher odds of several neurodevelopmental and allergic diagnoses, while second-born status tracked with substance abuse and gastrointestinal conditions. The observational study identified 150 significant birth-order associations across the phenome, but claims data and residual confounding prevent causal conclusions.

Older or younger sibling? Birth order could determine the diseases you get

A major study of 10 million people found birth order may influence disease risk, with first-born children and younger siblings showing different health patterns.

Birth order and disease risk across the human phenome: evidence from 10 million siblings

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