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Novo Nordisk's Wegovy cuts heart risk by 57% versus rival Lilly weight-loss drug in study

In the STEER study, Wegovy reduced major cardiovascular events by 57% compared to tirzepatide in US adults with obesity and cardiovascular disease without diabetes, Novo Nordisk reported.

  • Novo Nordisk said its weight-loss drug Wegovy reduced the risk of heart attack, stroke or death by 57% compared to Eli Lilly's rival medicines Mounjaro and Zepbound in overweight and obese patients with cardiovascular disease but not diabetes.
  • The study showed a 29% reduction in heart risk and death from any cause in Wegovy users compared with tirzepatide users, regardless of treatment gaps.
  • The findings could provide a boost for Novo, which has been losing U.S. market share to Zepbound since becoming Europe's most valuable company last year on booming sales of Wegovy.
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UOL broke the news in Brazil on Sunday, August 31, 2025.
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