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‘Next generation’ leukaemia drug approved on NHS

Obe-cel, a UK-developed CAR T-cell therapy, offers 77% remission in trials and fewer side effects for adults with relapsed B-cell acute lymphoblastic leukaemia.

  • A 'next generation' immunotherapy treatment called obe-cel, developed by the University College London spinout company Autolus, has the potential to cure leukaemia and has been approved for use in the NHS for those aged 26 and over.
  • Obe-Cel is a type of CAR T-cell therapy that genetically modifies cells to enable the body's own immune system to recognise and attack cancer, and only needs to be given once in a lifetime.
  • The National Institute for Health and Care Excellence has recommended obe-cel, stating that it could help more than 150 people over the next three years who have relapsed or refractory B-cell acute lymphoblastic leukaemia.
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Evening Standard broke the news in London, United Kingdom on Tuesday, November 25, 2025.
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