AAN and AHS Issue Updated Guideline on Migraine Prevention Medications for Adults
The update adds criteria for preventive treatment and weighs effectiveness, side effects, long-term safety and cost for newer CGRP-targeted drugs.
- On Monday, August 31, 2026, the American Academy of Neurology and the American Headache Society released a joint practice guideline update for migraine prevention, marking the first revision in 14 years.
- New evidence on treatments unavailable during the 2012 review is incorporated in this update, specifically the migraine-specific CGRP-targeted therapy category that has become a key preventive option.
- Roughly 8 million adults in the United States are now eligible for preventive treatment if they experience 4 or more migraine days per month or if migraine interferes with daily activities.
- Guideline author Rebecca Burch noted that clinicians now have specific recommendations based on factors patients prioritize, including effectiveness, side-effect profile, and cost, helping them feel more comfortable prescribing preventive treatments.
- Neurologic conditions are a leading cause of disability worldwide, and these new recommendations aim to reduce migraine frequency and severity by promoting personalized medicine and shared decision-making between clinicians and patients.
27 Articles
27 Articles
New guideline updates medications for preventing migraine in adults
To help clinicians determine which medications may be most effective at preventing migraine in adults, the American Academy of Neurology (AAN) and American Headache Society (AHS) have issued a joint practice guideline update with evidence-based recommendations, published on August 31, 2026, in Neurology®, the medical journal of the American Academy of Neurology, and in Headache, the official journal of the American Headache Society.
Updated guideline issued on migraine prevention medications for adults
To help clinicians determine which medications may be most effective at preventing migraine in adults, the American Academy of Neurology (AAN) and American Headache Society (AHS) have issued a joint practice guideline update with evidence-based recommendations, published in Neurology, and Headache. This update to the AAN and AHS 2012 guideline is endorsed by the American Academy of Family Physicians.
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