New Polygenic Risk Scores Improve Prediction of Metabolic Disease Outcomes

New polygenic risk scores improve prediction of metabolic disease outcomes

Type 2 diabetes (T2D) and obesity are metabolic conditions with many causes, including overlapping and distinct genetic features.

New genetic risk score better predicts diabetes, obesity and downstream complications

Type 2 diabetes (T2D) and obesity are metabolic conditions with many causes, including overlapping and distinct genetic features. A polygenic risk score (PRS) can capture multiple genetic risk factors to provide an estimate for whether a person may develop a complex medical condition and how they might fare long-term.

New genetic risk score better predicts metabolic conditions

By integrating genetic findings from several of the world's largest biobanks, investigators from Mass General Brigham built metabolic a polygenic risk score (PRS) for predicting obesity and type 2 diabetes (T2D), which capture multiple genetic risk factors to provide an estimate for whether a person may develop a complex medical condition and how they might fare long-term, and outperformed existing disease-prediction models and predicted downstr…

Polygenic Risk Score Better Predicts Obesity and Diabetes Across Ancestries

Type 2 diabetes (T2D) and obesity are metabolic disorders with many causes, including overlapping and distinct genetic features. A polygenic risk score (PRS) can capture multiple genetic risk factors to generate an estimate for whether a person may develop a complex medical condition and how they might fare long term. By integrating genetic data from several of the world’s largest biobanks, investigators at Mass General Brigham have now built me…