UBC Researchers Identify New Hereditary Form of Aggressive Prostate Cancer - Greenwood Boundary Creek Times
Researchers found inherited CDK12 mutations in 5 unrelated men and said the rare variant may support earlier screening for at-risk families.
- Researchers at the University of British Columbia have linked an inherited CDK12 gene mutation to aggressive prostate cancer, a discovery published in Cancer Discovery that could enable life-saving genetic screening.
- After analyzing genetic data from more than 4,500 patients, the team identified five men carrying the mutation, all of whom developed metastatic disease between the ages of 44 and 62.
- Although inherited CDK12 mutations affect only about one in every 1,000 people with aggressive prostate cancer, researchers identified links to ovarian cancer histories, suggesting testing could be added to ovarian cancer screening programs.
- "One of the most exciting aspects of this discovery is that we already have the technology needed to act on it," said Dr. Alexander Wyatt, a senior study author at the Vancouver Prostate Centre.
- UCLA researchers including Dr. Paul Boutros suggest combining inherited genetic markers with tumor sequencing improves risk assessment, with future efforts expanding these studies to diverse populations and refining therapeutic strategies.
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8 Articles
UBC researchers identify new hereditary form of aggressive prostate cancer - Grand Forks Gazette
Researchers at the University of British Columbia have linked an inherited gene mutation to an aggressive form of prostate cancer, possibly paving the way for new genetic testing that could save lives. After analyzing the genetic data for 4,500 prostate cancer patients, they found an inherited mutation in a gene dubbed CDK12 in five unrelated men, all of whom had developed an aggressive form of the disease between the ages of 44 and 62. The rese…
UBC researchers identify new hereditary form of aggressive prostate cancer - Vanderhoof Omineca Express
Researchers at the University of British Columbia have linked an inherited gene mutation to an aggressive form of prostate cancer, possibly paving the way for new genetic testing that could save lives. After analyzing the genetic data for 4,500 prostate cancer patients, they found an inherited mutation in a gene dubbed CDK12 in five unrelated men, all of whom had developed an aggressive form of the disease between the ages of 44 and 62. The rese…
UBC researchers identify new hereditary form of aggressive prostate cancer - Northern Sentinel
Researchers at the University of British Columbia have linked an inherited gene mutation to an aggressive form of prostate cancer, possibly paving the way for new genetic testing that could save lives. After analyzing the genetic data for 4,500 prostate cancer patients, they found an inherited mutation in a gene dubbed CDK12 in five unrelated men, all of whom had developed an aggressive form of the disease between the ages of 44 and 62. The rese…
UBC researchers identify new hereditary form of aggressive prostate cancer
Researchers at the University of British Columbia have linked an inherited gene mutation to an aggressive form of prostate cancer, possibly paving the way for new genetic testing that could save lives. After analyzing the genetic data for 4,500 prostate cancer patients, they found an inherited mutation in a gene dubbed CDK12 in five unrelated men, all of whom had developed an aggressive form of the disease between the ages of 44 and 62. The rese…
UBC researchers identify new hereditary form of aggressive prostate cancer - Kimberley Bulletin
Researchers at the University of British Columbia have linked an inherited gene mutation to an aggressive form of prostate cancer, possibly paving the way for new genetic testing that could save lives. After analyzing the genetic data for 4,500 prostate cancer patients, they found an inherited mutation in a gene dubbed CDK12 in five unrelated men, all of whom had developed an aggressive form of the disease between the ages of 44 and 62. The rese…
Researchers discover new form of hereditary prostate cancer
Researchers at the University of British Columbia have identified a new form of hereditary prostate cancer that, while rare, can cause aggressive disease at a young age. The discovery paves the way for genetic testing programs that could help identify at-risk families and support early cancer detection.
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