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Neanderthal males and human females had babies together, ancient DNA reveals

Genetic analysis shows Neanderthal DNA averages 1-2% in modern non-African humans and suggests male Neanderthals predominantly mated with female Homo sapiens.

  • On Feb. 26, the journal Science published a University of Pennsylvania study finding interbreeding was mostly between male Neanderthals and female anatomically modern humans.
  • Before this study, scientists suggested natural selection or incompatibility hypotheses to explain the 'Neanderthal deserts' in the human X chromosome.
  • Comparing Neanderthal and human genomes revealed Neanderthal X chromosomes carry 62% more human DNA than other chromosomes, a mirror pattern supporting mating behavior.
  • The study suggests this pattern helps explain present‑day Neanderthal ancestry, revealing why modern humans have low, uneven Neanderthal DNA affecting circadian rhythms, immune system function and pain.
  • The authors caution that alternatives remain plausible as the study cannot rule out lower survival of offspring from human males and Neanderthal females, and research is limited by a handful of high-quality Neanderthal genomes and modelling and simulations.
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This sexual bias would result either from a preference for a partner or from a demographic process.

·Montreal, Canada
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A genetic reconstruction shows that about three quarters of the known blends took place in southern Europe and mainly Neanderthal fathers were involved.

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The men of Neandertal and the women of Homo Sapiens were particularly inclined to mate, reveals a new study published in the journal Science.

·Montreal, Canada
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Nature broke the news in United Kingdom on Thursday, February 26, 2026.
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