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NBC: Why many MS patients like Christina Applegate are misdiagnosed

Experts say nearly 1 in 5 people told they have multiple sclerosis later learn they do not, often after more advanced testing.

  • On Tuesday, Actor Christina Applegate announced she was misdiagnosed with multiple sclerosis after years of believing she had the condition, sharing the news on her podcast, MeSsy.
  • Experts describe multiple sclerosis misdiagnosis as "fairly common" because no single test confirms the condition, and symptoms often mimic other autoimmune or neurological disorders.
  • Research indicates that between 15% and 20% of patients diagnosed with multiple sclerosis do not actually have the condition, with studies showing misdiagnosis rates ranging from 5% to 41%.
  • Dr. Robert Brumel of the Cleveland Clinic advises patients to seek a second opinion if concerned, noting that advanced MRI sequences can help differentiate lesions from other conditions.
  • Applegate stated she is "back at square one" regarding her health, as doctors launch an investigation to determine the cause of her debilitating symptoms since 2021.
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Emmy Award-winning actress Christina Applegate says she was misdiagnosed with multiple sclerosis, which she believed she had for more than five years.

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After believing for years to suffer from multiple sclerosis, Christina Applegate reveals that she did not suffer from this disease. "I came back to square one" and it is a "psychological shock," she insurges the actress. Victim of a false diagnosis. Christina Applegate recently learned that she was not finally suffering from multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord. The 54-year-old American actress co…

·Issy-les-Moulineaux, France
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NBC Chicago broke the news in Chicago, United States on Tuesday, October 20, 2026.
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