Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

Innovative antivenom is a ‘potential game changer’ for snakebites

Synthetic cocktail of llama and alpaca “nanobodies” protected mice from venoms of 17 snakes

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

Each year, snakebite envenoming claims thousands of lives and causes severe injury to victims across sub-Saharan Africa, many of whom depend on antivenoms derived from animal plasma as their sole treatment option1. Traditional antivenoms are expensive, can cause adverse immunological reactions, offer limited efficacy against local tissue damage and are often ineffective against all medically relevant snake species2. There is thus an urgent unmet…

Nanobody Antivenom Targets Cobra, Mamba, Rinkhals

In a breakthrough development poised to revolutionize the treatment of venomous snakebites, researchers have engineered a novel recombinant antivenom that demonstrates remarkable efficacy against the devastating dermonecrosis caused by bites from cobra, mamba, and rinkhals species. Traditional plasma-derived antivenoms, while life-saving, often fall short in mitigating local tissue destruction, leading to severe morbidity, including permanent […]