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Published 3 months ago

Mutated gene 'found in 4% of people' could help scientists tackle obesity

  • Scientists have discovered a gene variant, ZFHX3, that regulates body weight and appetite, which could help combat obesity.
  • The mutated ZFHX3 gene affects the hypothalamus in the brain, controlling appetite and weight. Understanding this mechanism could lead to targeted weight loss therapies.
  • Mice with the ZFHX3 mutation had lower food intake, shorter body length, and lower levels of insulin and leptin, suggesting healthier blood sugar regulation and reduced risk of diabetes and heart disease.
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