US EditionLess than two years after stopping obesity drugs, weight and health issues return, study finds
Oxford researchers found people regain weight at 0.4 kg per month after stopping GLP-1 drugs, with health benefits reversing in about 1.4 years, urging long-term obesity management.
- On Thursday, University of Oxford researchers found stopping GLP-1 injections leads to rapid weight regain within less than two years and reverses cardiometabolic improvements.
- GLP-1 receptor agonists mimic a gut hormone, stimulating insulin, slowing stomach emptying and reducing appetite, but when treatment stops, biological drivers return, prompting rapid weight regain, Dr Adam Collins said.
- A meta-analysis of 37 clinical trials pooling 9341 participants found average treatment time 10 months and average follow-up eight months, with 8.3kg weight loss during treatment.
- Cost and access issues mean the NHS caps semaglutide at two years, while almost two million British adults used the jabs last year, Jebb said, `One would expect that these treatments need to be continued for life.`
- Separate analyses warn that long-term strategies, including behavioural support, are essential since Garron Dodd states, 'This new data makes it clear they are a starting point, not a cure.
94 Articles
94 Articles
According to a study, the so-called jojo effect is particularly pronounced after the end of a treatment with so-called weight loss syringes. An overview study in the British Medical Journal with data from more than 9,000 people shows that those who dropped the drug were on average back at baseline within less than two years - four times faster than those who had relied on healthy nutrition and exercise.
You didn't really think weight loss jabs would fix everything, surely?
So what do you know? In the least surprising item of breaking news so far in 2026, it turns out that there is no such thing as a free lunch. I use this metaphor advisedly, because I am referring to the discovery that slimming drugs such as Wegovy and Mounjaro are not, in fact, the shortcut to long-term weight loss. An Oxford University study has concluded that users of these drugs will regain all the weight they lost within 18 months of stopping…
A systematic review by researchers at the University of Oxford Biomedical Research Center found that people tend to gain weight quickly after they stop taking weight loss medications, and much faster than after completing behavioral weight loss programs.Read more]]>
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