Molecular 'Self-Destruct' Switch Discovered: How Stressed Cells Decide Between Survival and Death
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5 Articles
Molecular 'self-destruct' switch discovered: How stressed cells decide between survival and death
A new study from Ben-Gurion University of the Negev (BGU) has identified a molecular switch that controls whether stressed human cells activate a survival mechanism or trigger programmed cell death (apoptosis). The findings, published in Redox Biology, provide insights that could help overcome chemotherapy resistance in aggressive tumors.
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elcorreogallego.esIsraeli researchers have identified a molecular switch that acts as a decision point between the survival and death of cells under stress. The finding, focused on DNAJB12 and DNAJB14 proteins and on signaling the endoplasmic reticulum, could provide new clues to combat the resistance of some tumors to chemotherapy.
Science and Heitech: Scientists at Ben Gurion University have discovered the exact chemical mechanism by which stress cells decide whether to save life or launch an apoptosis.
Whether stressed cells adapt or die obviously depends on a chemical tipping point in the endoplasmic reticulum. Cell experiments show that two protective proteins support a survival path under moderate stress, but are degraded under severe stress. This could explain how tumor cells resist chemotherapy, but so far is only a possible therapeutic approach. Beer-Sheva (Israel). The endoplasmic reticulum (ER) produces and folds a large part of the ce…
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