Design 'Molecular Scissors' that Stop HIV in Lab Cells
6 Articles
6 Articles
, an advance that demonstrates that it is possible to damage the genome of this virus in such a wide way that the virus cannot be repaired or propagated. The technique, developed by scientists of the Institute of Parasitology and Biomedicine López-Neyra of the Higher Council of Scientific Research of Granada (south of Spain) in collaboration with an international group ... Continue reading "Scientists manage to stop HIV through ’molecular scisso…
A research team has managed to eliminate some of the DNA from the Human Immunodeficiency Virus (HIV) that was integrated into cells infected in the laboratory, through 'molecular scissors', an advance that demonstrates that it is possible to damage the genome of this virus so widely that the virus cannot be repaired or propagated.The technique, developed by scientists from the Institute of Parasitology and Biomedicine López-Neyra of the Higher C…
Andalusian CSIC researchers manage to inactivate the virus in up to 97% of the cells treated in the laboratory
They manage to remove up to 97% of the HIV DNA integrated with CRISPR-SaCas9 in in vitro cells and leave it inactive, although ex vivo and mouse safety need to be validated.
(EFE).- A research team managed to remove some of the DNA from the Human Immunodeficiency Virus (HIV) that was integrated into laboratory infected cells, using ‘molecular scissors’, a breakthrough that demonstrates that it is possible to damage the genome of this virus so widely that the virus cannot be repaired or propagated.
The next steps will be to validate the strategy in ex vivo treated patient cells, i.e. with samples taken from an organism but analyzed or treated outside the body, test it in humanized rat models and continue to evaluate its safety.
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