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Modulating Cholinergic Hyperactivity Restores Motor Deficits in Parkinson's Disease, Revealed by Quantitative [18F]VAT PET Imaging Vesicular Acetylcholine Transporter

Summary by researchsquare.com
To investigate the role of cholinergic neuronal activity in Parkinson's disease (PD), A53T transgenic mice underwent [18F]VAT PET imaging targeting the vesicular acetylcholine transporter. Baseline scans revealed cholinergic hyperactivity in multiple brain regions including amygdala...
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Modulating Cholinergic Hyperactivity Restores Motor Deficits in Parkinson's Disease, Revealed by Quantitative [18F]VAT PET Imaging Vesicular Acetylcholine Transporter

To investigate the role of cholinergic neuronal activity in Parkinson's disease (PD), A53T transgenic mice underwent [18F]VAT PET imaging targeting the vesicular acetylcholine transporter. Baseline scans revealed cholinergic hyperactivity in multiple brain regions including amygdala...

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researchsquare.com broke the news in on Thursday, September 11, 2025.
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