Mitochondria May Control Immune Cell Activation and the Effectiveness of Immunotherapy

Mitochondria may control immune cell activation and the effectiveness of immunotherapy

A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial checkpoint that enables dendritic cells to efficiently activate T lymphocytes against viruses and tumors. Dendritic cells are immune cells that detect threats and activate the body's defenses, acting as sentinels that instruct T lymphocytes on what to attack.

Mitochondria Drive Immune Cell Activation and Boost Immunotherapy

In a groundbreaking study that unveils a crucial metabolic dimension in immune activation, researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified mitochondrial complex I as an essential driver of dendritic cell functionality. Their findings, recently published in Science Immunology, illuminate a previously unappreciated “mitochondrial checkpoint” necessary for these pivotal immune cells to […]