This 1970s Compound Can Burn More Fat Without Triggering Muscle Loss
5 Articles
5 Articles
Studies indicate that the combination of TOFA with other obesity medications improves the results in weight reduction and blood sugar levels
TOFA: Can it burn fat without making you eat less?
A new study suggests that TOFA, an experimental chemical compound, could offer a different approach to weight loss by increasing the body’s energy expenditure rather than suppressing appetite. In experiments involving obese male mice, TOFA helped reduce body fat, improve glucose control and liver fat, and increased energy use by up to 18 per cent without significant muscle loss, changes in physical activity or increased body temperature. Unlike …
An experimental substance caused male mice with diet-induced obesity to lose weight significantly over four weeks. The animals ate as much as before and lost mainly fat, while the researchers did not see any statistically significant reduction in fat-free mass. The substance is called 5-tetradecyloxy-2-furoic acid, abbreviated TOFA. It was developed under the name RMI 14,514 in the 1970s as a possible drug for high blood lipids. Early trials sho…
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