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Ancient-DNA Analysis Solves 500-Year-Old Mystery of What Killed 2 Medici Brothers

Researchers found a novel Plasmodium falciparum strain in Giovanni and traces of two malaria species in Francesco, resolving a long debate over his death.

Summary by Live Science
Two brothers from the wealthy and powerful Medici family died of malaria and were not poisoned as a rumor had suggested, archaeologists have confirmed based on a DNA analysis of the brothers' skeletons. The analysis also revealed a unique, mutated strain of malaria that may hold the key to understanding the evolution of the disease in Europe.The Medici family rose to power in the 15th century by creating the largest bank in Europe. The family us…

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New research has investigated one of the mysterious deaths of the Medici family. Long suspected of poisoning, political intrigue, and murder, the truth has been revealed.

·Budapest, Hungary
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Yale University broke the news on Tuesday, June 30, 2026.
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