Massive Protein Interaction Map Reveals How Muscles Fall Silent to Insulin

Massive Protein Interaction Map Reveals How Muscles Fall Silent to Insulin

Insulin resistance in skeletal muscle is one of the earliest and most consequential steps on the road to type 2 diabetes, yet the molecular events that disable the muscle cell’s response to insulin have remained only partially understood. Most research to date has focused on changes in the abundance of individual proteins or the addition of phosphate groups to signalling molecules. A team led by Benjamin L. Parker at the University of Melbourne …