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Lions vs. Bills prediction, odds: 'Thursday Night Football' picks from proven model

The model projects 58 combined points and says the Over has value in 57% of simulations.

Summary by CBS Sports
The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game
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Bias Distribution

  • 75% of the sources lean Left
75% Left

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Ownership

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USA Today broke the news in New York, United States on Wednesday, September 16, 2026.
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