A needle-free vaccination method protected mice against the viruses that cause COVID-19 and flu, offering a possible new way to deliver mRNA vaccines while limiting unwanted inflammation.
mRNA vaccines can be administered without needles or lipid nanoparticles, which help deliver genetic material into cells. Scientists have developed an experimental method that uses a high-pressure liquid jet and a combination of two immune-boosting substances. In mice, the formulation provided protection against SARS-CoV-2 and the influenza A virus.