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Key Alzheimer's protein actively protects neurons from nuclear damage
Researchers say APP helps neurons clear nuclear debris through lysosomal exocytosis, while reduced or mutant APP leaves cells with more inflammation and death markers.
Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP), a molecule long studied as the precursor to amyloid-β (Aβ) in Alzheimer's disease (AD).